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|CAS:||1341-23-7||Synonyms:||NR , Nicotinatide Riboside , N-Ribosylnicotinamide , 1-(β-D-Ribofuranosyl)nicotinamide|
|Molar Mass:||255.25 G/mol||Formula:||C11H15N2O5+|
Nicotinamide Riboside Powder,
nicotinamide riboside synthesis
Anti Aging Nicotinamice Riboside 1341-23-7 NR N-Ribosylnicotinamide
We can supply Nicotinamide Riboside capsules.
250 mg / tablet
Nicotinamide Riboside (NR) is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.
NR was first described as a growth factor, termed Factor V. Factor V, purified from blood was shown to exist in three forms, NAD+, NMN and NR. NR is demenstrated a natural product.
You are about to join the thousands of people who are already taking advantage of the latest breakthrough in the science of aging. You may be facing unique age-related health concerns. And things are only going to get harder as your body grows older. Fortunately, studies have shown that raising levels of NAD+ may reverse many of the effects caused by aging. Taking Nicotinamide Riboside daily can support.
Nicotinamide Riboside: Anti-Aging Miracle Or Scam?
A while back, I came across an article about mitochondrial health as a reversible cause of aging. It was written by a team of researchers led by Harvard Geneticist David Sinclair. It’s about levels of a chemical called NAD, which is responsible for proper communication between cell nuclei and mitochondria.
The team found a way to boost NAD production, which in turn enhances communication within cells. I was vaguely familiar with David Sinclair and his work on anti-aging advancements with resveratrol, but this article made a big claim: they claimed to have unlocked the answer to aging.
I’ve always been hugely interested in the science of aging, and how we’ll fight aging both in the near and distant future.
Especially methods of fighting aging that don’t involve rubbing infant foreskin serum on your skin.
According to this article from PubMed, a Cornell team took Sinclair’s discoveries a step further, showing that an NAD precurser called Nicotinamide Riboside is bio-available through oral ingestion. In both tests, the scientists took lab mice, and supplemented their diets with a healthy serving of NR. The results were nothing short of astounding.
How Nicotinamide Riboside Works
There’s basically three important pieces of this puzzle. NAD+, Nicotinamine Riboside (NR) and Sirtuin Enzymes, all of which relate to the nucleus, mitochondria, and most importantly, the communication between the two in every cell.
It all begins with the mitochondria. Mitochondria have long been known as the “power houses” of our cells, as they are responsible for energy production in each specific cell; and therefore, throughout our entire body.
The nucleus, on the other hand, is the controller of the cell. The nucleus ensures that everything inside of the cell is going well, that all of the “employees” at “Cell Corporation” are doing their jobs effectively.
The problem, as Sinclair and Cantó, et al. discovered, occurs when communication between these two important organelles breaks down. When that happens, the cells begin to suffer the effects of age, producing less energy and not working as efficiently as possible. This failure manifests itself in aging – both in the skin, and in the skeletal and muscle structure.
That is to say, when the nucleus and mitochondria don’t communicate properly, everything falls apart.
This is where the three puzzle pieces fit in. This communication is promoted by an enzyme called Sirutin 1, or SIRT1. This enzyme is responsible, essentially, for ensuring outside molecules don’t interrupt the traffic between the nucleus and the cell wall.
SIRT1, in turn, is activated by a chemical called NAD+. NAD+ is what’s known as a co-substrate, which is basically an activator – a compound that ensures the activation of a certain molecule. NAD+ is the most important part of this whole equation.
Luckily for us, NAD+ is a naturally occurring molecule in our body. Without it, our cells would die quickly. Unluckily, NAD+ levels decline as we age, resulting in wrinkles, bone deterioration, and muscle decline.
This is where Sinclair and Cantó, et al.’s research comes in. They identified a new vitamin that can stoke the production of NAD+ — without the side effects of other NAD+ precursors like Nicotinic Acid, which causes severe flushing.
This NAD+ producer is nicotinamide riboside. In both studies, the mice who were supplemented with NR showed powerful anti-aging effects, metabolic energy increases and improvements in cell repair and upkeep. This suggests that supplementation with this new vitamin is a possible key to halting the effects of aging.
Even more interesting, Cantó, et al. suggest that NR can also be used to “ameliorate metabolic and age-related disorders”. This can be applied to problems that arise from our metabolism and aging problems, like arthritis and type 2 diabetes.
It is important to note that these two studies have only been used on mice. There is a bit of a gap as far humans go. Specifically, the amount of NR necessary to induce a change is, at the current moment, nebulous.
Human Dosing Controversy
In Cantó, et al.’s research, they supplemented the mice with a daily amount of 400 milligrams of NR per each kilogram of body mass. Translated to a human that weighs about 150 pounds, you’re looking at 28000 milligrams of NR per day, or 28 grams a day.
Standard dosing for retail nicotinamide riboside, marketed under the names Niagen, N(R) and a few others, is typically 250mg a day.
In fact, some people are so obsessed with mega-dosing NR that there’s a thread on longecity.org dedicated to nicotinamide riboside group buy.
So the question becomes, can nicotinamide riboside be effective at available doses?
It turns out, the answer is possibly yes.
When I first wrote this article, I made a common mistake when extrapolating dosing from animals to humans. My calculation was based only on a body mass conversion.
A source contacted me, citing a paper by Reagan-Shaw, et al. titled, Dose translation from animal to human studies revisited.
According to the paper:
The animal dose should not be extrapolated to a human equivalent dose (HED) by a simple conversion based on body weight, as was reported. For the more appropriate conversion of drug doses from animal studies to human studies, we suggest using the body surface area (BSA) normalization method. BSA correlates well across several mammalian species with several parameters of biology, including oxygen utilization, caloric expenditure, basal metabolism, blood volume, circulating plasma proteins, and renal function.
Using this methodology and the formula for BSA translation, a more accurate dose translation from rats to 150 pound human roughly yields a daily dose around 2200mg. This is considerably closer to the currently available retail options and a source tells me that a current human study has subjects on doses nearing that number and that we will know a lot more about accurate dosing and efficacy the near future.
With clinical trials in the works, Nicotinamide Riboside is available now.
What if, retail doses actually work?
What if, in humans, a small boost to our cells can actually slow or even reverse aging?
Every day is the shortest day of our lives. Every day, we get older.
Is skepticism causing us to miss out on real opportunity to support our longevity?
What if, twenty years from now, nicotinamide riboside is as common as a Flintstones Vitamin, and all those years, we’ve missed out?
What does this mean for us?
Although the discourse about life extension typically takes place in the arena of bionics and robotic augmentation, nicotinamide riboside suggests the possibility of natural answers to the aging “problem.”
These scientific breakthroughs in simple life-extending vitamins like NR are only the first few steps toward a world with natural life extension possibilities. It’s a field of study that is still in its infancy.
As we refine our thinking, there’s a possibility that supplements like NR can push us deep into the 21st century. So deep, in fact, that there’s a distinct possibility, as science continues to progress, that we could live to see the 22nd and even the 23rd.