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|Molar Mass:||817.9||PubChem:||CID 6918245|
|Synonyms:||Growth Hormone Releasing Peptide-2; GHRP2; GHRP 2||CAS:||158861-67-7|
egf growth factor,
recombinant growth factors
158861-67-7 Pralmorelin Epidermal Growth Factor Growth Hormone Releasing Peptide GHRP 2
GHRP-2 (also known as KP 102 or Pralmorelin) is a synthetic hexapeptide Growth Hormone Releasing Peptide (GHRP), which acts on the hypothalamus and the pituitary gland to release growth hormone with a slight stimulator effect on Prolactin, ACTH and Cortisol levels. GHRP-2 is considered to be a true hGH secretagogue, meaning that it stimulates the body’s own secretion of hGH. Human Growth hormone has been shown in studies to promote lean body mass and reduce adiposity (fat). GHRP2 has demonstrated that it is very effective at stimulating GH production in research test subjects. It has a short half life with peak concentrations occurring around 15 minutes and not longer than 60 minutes after administration.
Molecular formula: C45H55N9O6
Molar Mass: 817.9
CAS number: 158861-67-7
PubChem: CID 6918245
Synonyms: Growth Hormone Releasing Peptide-2; GHRP2; GHRP 2
GHRP2 (Growth Hormone Releasing Peptide 2) also known as Pralmorelin
GHRP-2 and GRF Analogue Interactions (CJC-1295 / Sermorelin)
It is important to know that GHRP-2 does not relate to any Growth Hormone Releasing Hormones (GHRH) peptides such as Sermorelin and CJC-1295 because it acts on different receptors. However, greater results occurred when administered in conjunction with a Growth Hormone Releasing Hormone (GHRH) such as Modified GRF 1-29 or CJC-1295 dDAC.
Naturally, these GHRP-2 peptide receptors interact with a hormone called ghrelin. Growth hormone releasing peptide 2 is a commercially synthesized, non-natural super-analog of GHRP-6 which is capable of potent stimulatory effect on growth hormone (GH) secretion with slight stimulator effect in PRL, ACTH and levels of cortisol (Arvat et al. 1997). It is also a synthetic agonist of ghrelin that is binding with the growth hormone (GH) secretagogue receptor. GHRP-2 has been shown to affect and induce growth hormone secretion. The response of natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of growth hormones in response to this peptide (Wu et al. 1994).
Comparing GHRP-2 and GHRP-6 (Growth Hormone Releasing Hexapeptide)
GHRP-2 is a 2nd generation GHRP just behind GHRP-6. Compared to GHRP-6, GHRP-2 is considered to be much more superior in terms of growth hormone stimulation because over longer periods of time it maintains maximum elevations in Growth Hormone. GHRP-2 has shown to increase IGF-1 levels (Insulinlike Growth Factor 1), and even greater results happen when used with Growth Hormone Releasing Hormone (GHRP). It has a short half life with peak concentrations occurring around 15 minutes but not longer than 60 minutes.
The response of natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of growth hormones in response to the high-amplitude pulsation from the GHRP-2. GHRP-2 and other ghrelin analogues increase the number of somatotropes involved in the GH pulse by inhibiting somatostatin, GHRH increases the pulse amplitude per pituitary cell or somatotrope by other means. Unlike ghrelin, GHRP-2 is not lipogenic which means that it does not induce fat storage. Although ghrelin plays a large role in hunger, GHRP-2 as an analog of ghrelin does not increase appetite significantly.
The Utility of GHRP-2 as a Growth Hormone Secretagogue
GHRP-2 has been studied extensively for its utility as a growth hormone secretagogue (GHS). Scientists have discovered that the Growth Hormone Releasing Peptide-2 increases the natural production of growth hormone (GH). In the early 90’s, one of the most famous studies was performed and later published in 1997 in the Journal of Endocrinology and Metabolism. This study further exemplifies the theory that growth hormone releasing peptides (including Ipamorelin and (GHRP) could help hormone deficient adults and children. Ever since these major scientific studies, GHRP-2 has been widely produced.
With other scientific labs confirming the results from their studies, GHRP-2 can in fact work for those who lack the ability to make adequate human growth hormone. Results however will differ with the use of GHRP-2 because species respond differently based on the pituitary somatotrophs and the differences in the subtypes of GHRP receptors. In the physiologic system, the actions are blocked by GRF receptors antagonist which acts through a different receptor to that employed by earlier GHRPs.
GHRP-2 for hGH Therapy
GHRP-2 (Growth Hormone Releasing Peptide -2) is a non-natural, commercially synthesized, super-analog of Growth Hormone Releasing Peptide-6 (GHRP-6) which is competent enough to strongly stimulate effect on human growth hormone (HGH). It is a peptide which also plays a role as an agonist (activator) of ghrelin, the recently-found gut peptide. Ghrelin peptide binds to the secretagogue receptor of growth hormone (GH) and produces an urge for food as well as stomach emptying.
GHRP-2 has been widely studied for its helpfulness and action as a growth hormone secretagogue (GHS), meaning it stimulates the secretion of growth hormone. This is a hexapeptide with potent properties. It is known to promote hunger and appetite by stimulating Ghrelin release.
The best use of GHRP-2 is correcting the production of low level of growth hormone. GHRP-2 also brings about an excess weight gain in unusually lean individuals. GHRP-2 therapy is regarded as one of a few medical techniques of reversing the aging effects in people lacking this important growth hormone. This benefit results from the boosted and better stimulation as well as release of human growth hormone by our pituitary gland.
GHRP-2 is basically a sterile white lyophilized powder. It is considered to be the most potent classes of the GHRP family. This peptide has been demonstrated to be helpful in adults and can be given through the oral, intravenous as well as intra-nasal route.
How Does GHRP-2 Boost hGH Levels?
Growth Hormone Releasing Peptide-2 (GHRP-2) works to substantially activate the pituitary gland. This causes an increase in the production of the endogenous growth hormone. Thus, this peptide works to enhance your body’s own hormone which in turn brings about functionality from the natural hormone of the body without any of the adverse effects associated with synthetic growth hormone use.
GHRP-2 enhances hGH production via a two-fold mechanism of action, for instance, a) it causes an increase in growth hormone via amplification of the transduction pathway of the natural growth hormone releasing hormone signal, and b) it suppresses the actions of somatostatin, thus both these pathways brings about an increase in the level of endogenous growth hormone.
GHRP-2 therapy requires a daily dosage administered via subcutaneous, oral or intra-nasal route. Growth Hormone releasing peptide 2 also possesses an ability to vigorously boost levels of IGF-1. In order to achieve higher results, it can be used in combination with Growth Hormone Releasing peptide 6 (GHRP) and Sermorelin, both of which activate the pituitary gland to manufacture higher natural human growth hormone. In addition, this combination increases the function of hypothalamus as well.
Advantages Of GHRP-2 Over hGH
GHRP-2 has a number of advantages over hGH replacement therapy as stated below:
1. GHRP -2 enhances the production as well as the release of the body’s own natural growth hormone whereas hGH replacement therapy offers only exogenous human growth hormone and can actually shut-down natural growth hormone production.
2. When hGH replacement therapy is administered alone, not only can it cause unwanted side effects, but also it suppresses the body’s ability to synthesize hGH. (GHRP-2 does not have this effect).
3. The use of GHRP-2 coupled with hGH replacement therapy helps to achieve boosted levels of natural human growth hormones as compared to hGH replacement therapy alone.
4. Furthermore, growth hormone has a short half life and is unproductive when given orally, as it moves into the gastric tract and undergoes metabolism by the liver. For this reason, hGH should only be administered via the subcutaneous route.
On the other hand, GHRP-2 delivery via an oral route along with intra-nasal or sublingual has been shown to be effective alternative technique of supplement administration or systemic medicine withremarkable results and a number of advantages over both enteral and injectable routes of administration.
Since the oral mucosa is richly supplied with blood vessels and thus it offers direct entry of a drug into the systemic circulation, with the advantage of bypassing the gastrointestinal tract (GIT) as well as first pass metabolism in the liver. This leads to speedy onset of action of a supplement together with a convenient and easy route of delivery.
Benefits of GHRP-2
In addition to the multitude of advantages listed above, GHRP-2 offers a number of other benefits without any adverse effects such as:
1. It enhances enduranceBenefits of GHRP-2
2. Makes the heart strong
3. Decreases fat via lipolysis
4. Inhibits the uptake of glucose by the liver and thus works in opposition to insulin
5. Helps to maintain the function of the pancreas
6. Stimulates the process of glucogenesis by the liver
7. It increases the retention of calcium and thus makes the bone strong by enhancing bone mineralization.
8. GHRP-2 strengthens the immune system
9. Boosts production of IGF-1 which offers an anabolic (muscle building) effect in turn
10. Speeds up the wound healing or healing following a surgery
11. Improves sex desire and drive and it does so by hypothalamus stimulation
Recent research has also disclosed that GHRP-2 can be administered in higher doses than primarily considered, while staying away from desensitization which is natural in some of the other groups of GHRP. This offers the consumer with the chance to experience higher increases in total growth hormone, depending on the quantity administered.
Safety of GHRP-2
GHRP-2 has been confirmed to be a safe alternate for synthetic hGH and it has been proven by a number of scientists. If it is administered within the suggested dose, it is almost free of any kind of adverse events. However if you try to use in excess, then obviously certain unfavorable events are likely to occur such as water retention, tingling and numbness in the extremities or tiredness.
Overall, GHRP-2 is quite safe and less risky as compared to hGH which unfortunately comes with a range of known side-effects.