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|Molar Mass:||414.621 G/mol||Formula:||C27H42O3|
|ECHA InfoCard:||100.005.584||Synonyms:||NSC-64967; SH-601; SQ-16374 , Primobolan Depot|
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Methenolone Enanthate Tren Anabolic Steroid 303-42-4 SH-601 Primobolan Depot
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Metenolone enanthate, or methenolone enanthate, is a dihydrotestosterone (DHT)-based anabolic-androgenic steroid (AAS). It is an ester derivative of metenolone sold commonly under the brand name Primobolan Depot (injectable). When it interacts with the aromatase enzyme it does not form any estrogens. It is used by people who are very susceptible to estrogenic side effects, having lower estrogenic properties than nandrolone.
Metenolone, in form of enanthate and acetate (see metenolone acetate), is available as an injection or as an oral formulation, respectively. The injection is regarded as having a higher bioavailability. It is an enanthate ester which is quite long-acting. Because it by-passes hepatic breakdown on the first pass, it also has a higher survival rate. The tablets are in a short-lived acetate form. Metenolone is not 17-alpha-alkylated, but 1-methylated for oral bioavailability. This reduces the stress on the liver, but also the availability. In doses of 200 mg per week or less (intramuscular) blood pressure is rarely altered.
Primobolan® Depot is the injectable version of the steroid methenolone. This of course is the same constituent in Primobolan© Orals (methenolone acetate), both produced by the firm Schering.
Primobolan ® Depot is the injectable version of the steroid methenolone. This of course is the same constituent in Primobolan© Orals (methenolone acetate), both produced by the firm Schering. In this preparation, an enanthate ester is added to the steroid, which causes a slow and gradual release from the site of injection. Its duration of activity would thus be quite similar to Testosterone enanthate, with blood levels remaining markedly elevated for approximately two weeks.
Methenolone itself is a long acting anabolic, with extremely low androgenic properties. On the same note the anabolic effect is also quite mild, its potency considered to be slightly less than DecaDurabolin® (nandrolone decanoate) on a milligram for milligram basis. For this reason, Primobolan is most commonly used during cutting cycles when a mass increase is not the main objective.
Some athletes do prefer to combine a mild anabolic like "Primo" with bulking drugs such as Dianabol, Anadrol 50® or testosterone however, presumably to lower the overall androgen dosage and minimize uncomfortable side effects. When choosing between Primobolan preparations, the injectable is preferred over the oral for ail applications, as it is much more cost effective.
Primobolan displays many favorable characteristics, most which stem from the fact that methenolone does not convert to estrogen. Estrogen linked side effects should therefore not be seen at all when administering this steroid. Sensitive individuals need not worry about developing gynecomastia, nor should they be noticing any water retention with this drug. The increase seen with Primobolan will be only quality muscle mass, and not the smooth bloat which accompanies most steroids open to aromatization.
During a cycle the user should additionally not have much trouble with blood pressure values, as this effect is also related (generally) to estrogen and water retention. At a moderate dosage of 100-200mg weekly, Primobolan® should also not interfere with endogenous testosterone levels as much as when taking an injectable nandrolone or testosterone.
This is very welcome, as the athlete should not have to be as concerned with ancillary drugs when the steroid is discontinued (a less extreme hormonal crash). At higher doses strong testosterone suppression may be noticed however, as all steroids can act to suppress testosterone production at a given dosage. Here of course an ancillary drug regimen may be indicated.
Side effects in general are usually not much of a problem with Primobolan® Depot. There is a chance to notice a few residual androgenic effects such as oily skin, acne, increased facial/body hair growth or an aggravation of male pattern baldness condition. This steroid is still very mild however, and such problems are typically dose related. Women will in fact find this preparation mild enough to use in most cases, observing it to be a very comfortable and effective anabolic. If both the oral and injectable were available for purchase, the faster acting oral should probably be given preference however. This is simply due to the fact that blood hormone levels are more difficult to control with a slow acting injectable, the user also having to wait many days for steroid levels to diminish if side effects become noticeable.
Overall, Primobolan® Depot is actually considered to be one of the safest anabolic steroids available. Steroid novices, older athletes or those sensitive to side effects would undoubtedly find it a very favorable drug to use. The typical "safe" dosage for men is 100-200mg per week, a level that should produce at least some noticeable muscle growth. In European medicine it is not uncommon for Primobolan® to be used safely at such a dosage for extended periods of time.
Among athletes, men may respond to weekly doses of 200mg but regular users will often inject much higher doses looking for a stronger anabolic effect. It is not uncommon for a bodybuilder to take as much as 600 or 800mg per week (6 to 8 100mg ampules), a range which appears to be actually quite productive. Of course androgenic side effects may become more pronounced with such an amount, but in most instances it should still be quite tolerable.
In addition, it is most popular for male bodybuilders to stack Primobolan® with other (generally stronger) steroids in order to obtain a faster and more enhanced effect. During a dieting or cutting phase, a non-aromatizing androgen like Halotestin® or trenbolone can be added. The strong androgenic component should help to bring about an added density and hardness to the muscles. On the other hand (or in addition) we could add Winstrol, another mild anabolic steroid. The result of this combination should again be a notable increase of muscle mass and hardness, but in this case the gain should not be accompanied by greatly increased side effects.
As mentioned earlier, Primobolan® Depot is also used effectively during bulking phases of training. The addition of testosterone, Dianabol or Anadrol 50® would prove quite effective for adding new muscle mass. Of course we would have to deal with estrogenic side effects, but in such cases Primobolan® should allow the user to take a much lower dosage of the more "toxic" drug and still receive acceptable results.
Women respond well to a dosage of 50-100mg per week, although (as stated above) the oral should usually be given preference. Additionally, some choose to include Winstrol® Depot (50 mg per week) or Oxandrolone (7.5l0mg daily) and receive a greatly enhanced anabolic effect. Remember though, androgenic activity can be a concern and should be watched, particularly when more than one anabolic is used at a time. If stacking, it would be best to use a much lower starting dosage for each drug than if they were to be used alone. This is especially good advice if you are unfamiliar with the effect such a combination may have on you. A popular recommendation would also be to first experiment by stacking with oral Primobolan®, and later venture into the injectable if this is still necessary.
On the black market, Primobolan® is in high demand and therefore is made readily available. Virtually all forms of this injectable steroid will be packaged in 1 ml glass ampules, with each containing 100mg of the drug in Europe and 50mg in Mexico (Germany also produces a 1 ml redi-ject). Inside the U.S., the 50mg ampules from Mexico and 100mg ampules from Spain and Greece most commonly show up. The attraction is no doubt the price, as Primobolan® is not an extremely cheap product. A single 100mg ampule will generally sell for around $15 to 20 in the United States. The 50mg ampule is usually a bit cheaper, perhaps $10 on average. Of course this is probably not as cost effective, and in worse cases this preparation will sell for about the same price as the 100mg version.
Methenolone is an anabolic androgenic steroid that was first released in 1962 by Squibb under the trade name Nibal (oral) and Nibal Depot (injectable). This was a very short-lived product on the U.S. market and by the mid-1960’s the German pharmaceutical powerhouse Schering would own all rights to the Methenolone hormone. Through Schering the hormone would be released as Primobolan (oral) and Primobolan Depot (injectable). The injectable Depot version will be our focus here. For information on oral Primobolan, please see the Primobolan profile.
Primobolan Depot represents one of the more popular anabolic steroids in performance enhancing circles, especially bodybuilding due to the Arnold Schwarzenegger stigma that surrounds it. It’s often been said this was his favorite anabolic steroid, and while he used it this stigma has created a misunderstanding of the steroid for some. This isn’t all that surprising, attach Arnold’s name to anything like this and you’ll make it sell.
Deca 200 Along with holding a bit of a unique stigma, Primobolan Depot carries one of the highest safety ratings among all anabolic steroids. This steroid is relatively mild and can be safe for both men and women. In fact, the steroid has even been used successfully in premature infants and children in specific therapeutic settings. The hormone is also well-known for having a solid record in the treatment of muscle wasting diseases, osteoporosis and sarcopenia, and is a great steroid for treating prolonged corticosteroid exposure. Primobolan has also been used effectively in the treatment of carcinoma, as well as hepatitis in some cases.
In a performance capacity, Primobolan Depot is not what we can call a strong mass promoting steroid. For the male athlete, it’s also not what we can call a foundational steroid. However, man or woman most will find Primobolan Depot to be far more effective and beneficial than its oral counterpart. Despite being a relatively weak mass builder, this steroid most certainly has its place in performance enhancement but the key to obtaining the benefits is understanding the proper points of use. This is where many steroid users fall short. They often expect certain things from certain steroids that it cannot do and are left scratching their head.
Primobolan Depot Functions & Traits:
Methenolone is a derivative of dihydrotestosterone (DHT) or more specifically a structurally altered version. The composition of the hormone is DHT with an added double bond at carbon positions one and two. This greatly increases the steroid’s anabolic nature. It also carries an added 1-methyl group, which in-turn protects the hormone from hepatic breakdown. In the case of Primobolan Depot, what we have is the Methenolone hormone with an added or attached Enanthate ester. This ester is added in an effort to control the hormone’s release time slowing it down substantially.
An important note, at one time injectable Methenolone Acetate was available. However, this product was discontinued in 1993. Currently, the only way you will obtain Methenolone Acetate is in oral Primobolan or through an underground lab that happens to manufacture an injectable version. However, injectable Methenolone Acetate is a bit of a rare product. If you’re going to use the Methenolone hormone in its injectable form, which is the preferred recommended form, Primobolan Depot is the only version most will have access to.
Primobolan Depot is a relatively mild anabolic steroid carrying an anabolic rating of 88 and an androgenic rating of 44-57. In order for these ratings to hold some teeth consider the rating system. All ratings are derived using the testosterone hormone as the baseline. Testosterone holds a rating of 100 in both categories. As you can see, Methenolone is a little weaker and while its anabolic rating isn’t that far off it is a little deceiving. Primobolan Depot will not provide as much lean tissue growth properties as its rating implies.
In its direct functioning capacity, Primobolan Depot offers several traits commonly found in anabolic steroids. The hormone has the ability to enhance protein synthesis and increase red blood cell count, as well as inhibit glucocorticoid hormones in the body. These traits do not manifest in Primobolan Depot as strongly as they do with many steroids, but they are in part what make this a valuable anabolic steroid. Where this steroid truly shines is in its ability to promote nitrogen retention in the muscles, as well as it possessing a strong binding affinity for the androgen receptor.
The enhanced nitrogen retention is important due to the fact that all muscle tissue is comprised of approximately 16% nitrogen. Low nitrogen levels will lead to a catabolic state, where as the more we retain the more anabolic we remain. Then we have the androgen receptor binding, this is important as such a trait has been linked to lipolysis. Almost all anabolic steroids promote a stronger and more powerful metabolism, but the strong binding affinity for the androgen receptor actually promotes direct fat loss. Coupled with the enhanced nitrogen retention, this makes Primobolan Depot an excellent cutting steroid.
The Methenolone hormone has also been shown to have a positive affect on the immune system. In cases of muscle wasting and immune issues such as with AIDS, Primobolan Depot has proven very useful. It may very well not be the only steroid used in such cases. As it won’t promote strong mass characteristics it probably won’t be the only one prescribed. However, the moderate anabolic nature along with immune enhancement makes it a top choice in these cases.
The ability of Primobolan Depot to enhance the immune system can also be very beneficial to every day steroid users. If your immune system is stronger, you’ll be healthier and have an easier time reaching your goals. But in the case of a cutting cycle it can be extremely valuable as immune systems often become a little weaker during a hard diet. This can hold very true among competitive bodybuilders who often go through diets for several months most people could not endure for a week.
Effects of Primobolan Depot:
As a bulking steroid in an off-season plan, Primobolan Depot is generally not the best choice. The steroid simply isn’t well-suited for a significant promotion in lean tissue mass. However, this is a steroid that cannot promote water retention as it lacks any estrogenic activity. Due to this fact any weight gained due to use will be 100% pure lean muscle mass, it simply may not be all that much.
When it comes to off-season use, we can, however, make an exception for females. Women are far more sensitive to the hormonal compound, and it may very well provide the anabolic boost they need for off-season growth. We’d actually call Primobolan one of the best anabolic steroids for female off-season use.
For those who are worried about a lot of excess mass, most women aren’t looking to gain 30lbs, remember total mass will largely be dependent on the individual’s diet and total steroidal dosing. Keeping the dose moderate and controlling your diet will enable you with the ability to easily control the amount of mass you want to gain. As a bonus, due to the metabolic enhancement and fat burning properties of this steroid, you will be able to gain off-season muscle mass with less body fat accumulation that would otherwise occur.
From off-season bulking the next point of discussion will be the cutting phase. Without question, man or woman this will be the best time to use Primobolan Depot. This is a fantastic steroid for protecting hard earned muscle tissue. In order to lose body fat, we must burn more calories than we consume. You can follow the healthiest diet on earth and exercise yourself into the ground, but if you do not burn more than you consume you will not lose body fat. Through this necessary caloric reduction, this can put our lean muscle mass at risk. The deficit will cause the body to pull what it needs for its energy demands from wherever it can.
The idea is to ensure it’s pulling from fat, but the body will be tempted to pull from muscle tissue in an effort to save body fat. This is part of the human bodies survival instinct. By supplementing with Primobolan Depot, we ensure our muscle mass is protected and fat is lost. We also ensure body fat is burned at a far more efficient rate. Those who use Primobolan Depot in this phase will also notice they are much harder and defined once body fat is low.
Primobolan Depot can also be a good steroid for athletic enhancement. It has the ability to promote increases in strength and will have a positive affect on muscular endurance and recovery. Equally important, as it’s not a powerful mass builder this can make it a great choice for many athletes. Many athletes don’t want to gain a lot of mass if any at all. In some cases, added mass may hinder performance. More importantly, staying away from rapid increases in muscle mass will protect the athlete from prying and suspicious eyes.